Description
Dysregulation of lipid metabolism plays a key role in the development and progression of metabolic disorders, including obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). We are seeking a highly motivated Scientist in Computational and Systems Biology to work on a project funded by the Swiss National Science Foundation (SNSF) aimed at advancing our understanding of human lipid metabolism in MASLD. The project focuses on modelling human metabolism by integrating clinical data with experimental models. It involves biochemical and molecular data from multiple tissues and biofluids to investigate tissue-specific metabolism, metabolic interactions across organs, and nutrient uptake, transformation, and release. The project combines statistical modelling, systems biology, and in silico metabolic modelling with clinical, transcriptomic, proteomic, metabolomic/lipidomic, spatial molecular imaging, and experimental metabolic flux data to provide new insights into the complex metabolic alterations underlying MASLD.
What you can expect
Develop and apply mathematical, statistical, and machine-learning models to complex, high-dimensional, and multimodal biological and clinical datasets, including spatial and imaging data
Model lipid and nutrient metabolism using compartmental, kinetic, mechanistic, metabolic network, or physiologically based approaches
Reconstruct and model tissue-specific metabolic networks and validate model predictions using experimental data
Participate in and contribute to multidisciplinary and collaborative research projects.
Prepare, present, and communicate scientific findings at internal meetings, international conferences, and through peer-reviewed publications
Your Profile
PhD or equivalent in computational biology, systems biology, applied mathematics, biochemical engineering, or a related field
Strong expertise in mathematical and statistical modelling, machine learning, and systems biology, with experience analysing high-dimensional, multimodal, or multi-omics biological or clinical data
Demonstrated experience in in silico metabolic modelling, e.g. constraint-based or genome-scale metabolic modelling, metabolic network reconstruction, kinetic or metabolic flux modelling, or data-driven simulation
Proficiency in R, , or MATLAB and experience integrating experimental data with computational models;
Experience in mass spectrometry, spatial omics, molecular imaging, or tissue imaging is a strong asset
Enthusiastic and collaborative scientist with strong analytical and problem-solving skills, the ability to work independently and in multidisciplinary teams, and excellent written and spoken English
What we offer
A supportive, collaborative, and state-of-the-art research environment with opportunities for scientific and professional development
Participation in multidisciplinary research projects at the interface of computational biology, systems biology, metabolism, multi-omics, molecular imaging, and clinical research
The opportunity to work with large datasets from pre-clinical and clinical studies
Close collaboration with experts from different scientific and clinical disciplines
Questions about the job?
For further information, please contact Prof. Mojgan Masoodi Head of Research
INSELSPITAL
3010 Berne
Postdoc in Computational Systems Biology and Metabolic Modeling
Dysregulation of lipid metabolism plays a key role in the development and progression of metabolic disorders, including obesity, type 2 diabetes, and metabolic dysfunction-associated steatotic liver disease (MASLD). We are seeking a highly motivated Scientist in Computational and Systems Biology to work on a project funded by the Swiss National Science Foundation (SNSF) aimed at advancing our understanding of human lipid metabolism in MASLD. The project focuses on modelling human metabolism by integrating clinical data with experimental models. It involves biochemical and molecular data from multiple tissues and biofluids to investigate tissue-specific metabolism, metabolic interactions across organs, and nutrient uptake, transformation, and release. The project combines statistical modelling, systems biology, and in silico metabolic modelling with clinical, transcriptomic, proteomic, metabolomic/lipidomic, spatial molecular imaging, and experimental metabolic flux data to provide new insights into the complex metabolic alterations underlying MASLD.
What you can expect
Develop and apply mathematical, statistical, and machine-learning models to complex, high-dimensional, and multimodal biological and clinical datasets, including spatial and imaging data
Model lipid and nutrient metabolism using compartmental, kinetic, mechanistic, metabolic network, or physiologically based approaches
Reconstruct and model tissue-specific metabolic networks and validate model predictions using experimental data
Participate in and contribute to multidisciplinary and collaborative research projects.
Prepare, present, and communicate scientific findings at internal meetings, international conferences, and through peer-reviewed publications
Your Profile
PhD or equivalent in computational biology, systems biology, applied mathematics, biochemical engineering, or a related field
Strong expertise in mathematical and statistical modelling, machine learning, and systems biology, with experience analysing high-dimensional, multimodal, or multi-omics biological or clinical data
Demonstrated experience in in silico metabolic modelling, e.g. constraint-based or genome-scale metabolic modelling, metabolic network reconstruction, kinetic or metabolic flux modelling, or data-driven simulation
Proficiency in R, , or MATLAB and experience integrating experimental data with computational models;
Experience in mass spectrometry, spatial omics, molecular imaging, or tissue imaging is a strong asset
Enthusiastic and collaborative scientist with strong analytical and problem-solving skills, the ability to work independently and in multidisciplinary teams, and excellent written and spoken English
What we offer
A supportive, collaborative, and state-of-the-art research environment with opportunities for scientific and professional development
Participation in multidisciplinary research projects at the interface of computational biology, systems biology, metabolism, multi-omics, molecular imaging, and clinical research
The opportunity to work with large datasets from pre-clinical and clinical studies
Close collaboration with experts from different scientific and clinical disciplines
Questions about the job?
For further information, please contact Prof. Mojgan Masoodi Head of Research
INSELSPITAL
3010 Berne jid409e4f3ob jit0936ob jiy26ob